Mesd - mesoderm development LRP chaperone Gene

Also Known as msd; mesd; Mesdc2; mKIAA0081; 2210015O11Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 67943

Summary

Enables identical protein binding activity and low-density lipoprotein particle receptor binding activity. Involved in phagocytosis and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within protein folding and protein localization to cell surface. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and ventricular layer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Apr 2022]

Mesd Products (2)

mRNA Protein Name
NM_001374090.1 NP_001361019.1 LRP chaperone MESD isoform 2
NM_023403.4 NP_075892.3 LRP chaperone MESD isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
21397184 MGI
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
16263759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16989816 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
27184668 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
24140340 MGI
acts upstream of or within protein folding IDA
IDA: Inferred from direct assay
16263759 MGI
involved in protein folding IMP
IMP: Inferred from mutant phenotype
21397183 MGI
acts upstream of or within protein localization to cell surface IDA
IDA: Inferred from direct assay
18505367 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
16263759 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LRP chaperone MESD

  • LDLR chaperone MESD

  • mesoderm development candidate 2

Mesd Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Mesd Q9ERE7 LRP5 Homo sapiens O75197
Anti Tag CoIP
15143163
Intra
Mesd Q9ERE7 Lrp5 Mus musculus Q91VN0
Anti Tag CoIP
12581525
Intra
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7
Solution Sedimentation
21397184
Intra
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7
X-Ray Diffraction
21397184
Cross
Mesd Q9ERE7 LRP6 Homo sapiens O75581
Anti Tag CoIP
16989816
Intra
Mesd Q9ERE7 Lrp6 Mus musculus O88572
Anti Tag CoIP
12581525
Intra
Mesd Q9ERE7 Mesd Mus musculus Q9ERE7
GMS
21397184
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-D0858S MES-d13 99.93% Unkown
HY-RS08341 MESD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19918 Mesd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26419 Mesd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Mesd NCBI NCBI:23184