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GDPD5 - glycerophosphodiester phosphodiesterase domain containing 5 Gene

Also Known as GDE2; PP1665

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 81544

About GDPD5

Cytogenetic location: 11q13.4-q13.5 Genomic coordinates (GRCh38): 11:75,434,640-75,525,941 (from NCBI)

This gene has 17 transcripts (splice variants), 274 orthologues and 5 paralogues. Broad expression in spleen (RPKM 16.9), fat (RPKM 8.6) and 14 other tissues.

Summary

Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]

GDPD5 Products (3)

mRNA	Protein	Name
NM_001351167.2	NP_001338096.1	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 2
NM_001351168.1	NP_001338097.1	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 3
NM_030792.8	NP_110419.5	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDPD5 Protein Structure

GDPD

0
100
200
300
400
500
605 a.a.

Protein Preferred Names	Protein Names
glycerophosphodiester phosphodiesterase domain-containing protein 5	glycerophosphocholine phosphodiesterase GDPD5

GDPD5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GDPD5	Q8WTR4	PEX5	Homo sapiens	P50542	Validated Y2H	25416956
Intra	GDPD5	Q8WTR4	PEX5	Homo sapiens	P50542	Y2H Array	25416956
Intra	GDPD5	Q8WTR4	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 41	MRD41 Autosomal Dominant Non-Syndromic Intellectual Disability 41 Mental Retardation, Autosomal Dominant 41 Autosomal Dominant Intellectual Developmental Disorder 41 Autosomal Dominant Mental Retardation 41 Mental Retardation, Autosomal Dominant, Type 41
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05365	GDPD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	GDPD5	RGD	RGD:1559673
Felis catus	GDPD5	VGNC	VGNC:62511
Macaca mulatta	GDPD5	VGNC	VGNC:72801
Canis familiaris	GDPD5	VGNC	VGNC:41170
Bos taurus	GDPD5	VGNC	VGNC:29313
Mus musculus	GDPD5	MGD	MGI:2686926
Others	GDPD5	NCBI