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SEC16A - SEC16 homolog A, endoplasmic reticulum export factor Gene

Also Known as p250; SEC16L; KIAA0310

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9919

About SEC16A

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,440,105-136,484,740 (from NCBI)

This gene has 15 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in stomach (RPKM 11.7), bone marrow (RPKM 11.4) and 25 other tissues.

Summary

This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]

SEC16A Products (2)

mRNA	Protein	Name
NM_001276418.2	NP_001263347.1	protein transport protein Sec16A isoform 2
NM_014866.2	NP_055681.1	protein transport protein Sec16A isoform 1

SEC16A Protein Structure

Sec16

Sec16_C

0
400
800
1200
1600
2000
2357 a.a.

Protein Preferred Names	Protein Names
protein transport protein Sec16A	protein SEC16 homolog A

SEC16A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SEC16A	O15027	DOCK7	Homo sapiens	Q96N67	Anti Bait CoIP	29187380
Intra	SEC16A	O15027	NBEAL2	Homo sapiens	Q6ZNJ1	Anti Tag CoIP	29187380
Intra	SEC16A	O15027	NBEAL2	Homo sapiens	Q6ZNJ1	Anti Bait CoIP	29187380
Intra	SEC16A	O15027	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	25201882
Intra	SEC16A	O15027	LRRK2	Homo sapiens	Q5S007	Confocal	25201882

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Craniolenticulosutural Dysplasia	Boyadjiev-Jabs Syndrome CLSD Cranio-Lenticulo-Sutural Dysplasia Cranio-Lenticulo-Sutural Dysplasia, Clsd
Mucinous Stomach Adenocarcinoma	Mucinous Adenocarcinoma Of The Stomach Mucinous Gastric Adenocarcinoma
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12609	SEC16A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	SEC16A	VGNC	VGNC:64963
Macaca mulatta	SEC16A	VGNC	VGNC:77326
Mus musculus	SEC16A	MGD	MGI:2139207
Canis familiaris	SEC16A	VGNC	VGNC:45965
Rattus norvegicus	SEC16A	RGD	RGD:2322350
Bos taurus	SEC16A	VGNC	VGNC:34406
Others	SEC16A	NCBI