GPR81 agonist 2
GPR81 agonist 2 is a GPR81 agonist with an EC50 of 0.023 μM for the human receptor. GPR81 agonist 2 activates the lactate-sensing receptor GPR81, inhibits forskolin-stimulated cAMP production and GTP binding of Gi protein. GPR81 agonist 2 can be used for research on type 2 diabetes.
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- CAS 番号: 1143024-28-5
- 分子式: C26H27ClN6O5S2
- 分子量:603.11
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
GPR81 0.023 μM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.023 μM
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Agonist activity against human GPR81 overexpressing CHO cells assessed by functional cell-based cAMP assay.
Agonist activity against human GPR81 overexpressing CHO cells assessed by functional cell-based cAMP assay.
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31932225 |
体外実験
GPR81 agonist 2 (compound 1) (10 μM) acts as a potent GPR81 agonist in CHO cells overexpressing hGPR81[1].
GPR81 agonist 2 has hGPR81 EC50 = 0.023 µM, hGPR109A EC50 = 0.123 µM, and hGHS-R1a IC50 = 0.008 µM; it shows poor selectivity for hGPR109A and hGHS-R1a[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1143024-28-5
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分子量 603.11
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分子式 C26H27ClN6O5S2
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SMILES
O=C(NC1=NC2=C(S1)C=C(S(=O)(C3CCN(CC3)C)=O)C=C2)NC(C4=C(Cl)C=C(OCC)C(N5N=CC=C5)=C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GPR81 agonist 2 関連分類
HY-148563 関連分類
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