Metopimazine
Based on 3 publication(s) in Google Scholar
Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 14008-44-7
- 分子式: C22H27N3O3S2
- 分子量:445.60
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Metopimazine
MoreDopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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D2 Receptor |
Metopimazine (10 μM; 60 min) has a brain permeability of 69.72% in an in vitro blood-brain barrier model of bovine brain capillary endothelial cells (BCEC) co-cultured with glial cells, while its metabolite metopimazine acid has a permeability of only 15.72%, which is significantly lower than that of the dopamine receptor antagonist control group[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14008-44-7
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性状 Solid
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分子量 445.60
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分子式 C22H27N3O3S2
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Color Off-white to light yellow
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SMILES
O=C(N)C1CCN(CC1)CCCN2C3=C(SC4=CC=C(C=C24)S(=O)(C)=O)C=CC=C3
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別名
EXP999; RP9965
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
PPAR Res
Activation of PPAR γ Protects Obese Mice from Acute Lung Injury by Inhibiting Endoplasmic Reticulum Stress and Promoting Mitochondrial Biogenesis. [Abstract]2022 Sep 28:2022:7888937. PMID: 36213491
溶剤 & 溶解度
DMSO : 50 mg/mL (112.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Victoire Roussel, et al. Estimating the excess of inappropriate prescriptions of anti-dopaminergic anti-emetics during acute gastroenteritis epidemics in France. Pharmacoepidemiol Drug Saf. 2013 Oct;22(10):1080-5. [Content Brief]
[3]. Jolliet P, et al. Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier. Pharmacol Res. 2007 Jul;56(1):11-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2442 mL | 11.2208 mL | 22.4417 mL | 56.1041 mL |
| 5 mM | 0.4488 mL | 2.2442 mL | 4.4883 mL | 11.2208 mL | |
| 10 mM | 0.2244 mL | 1.1221 mL | 2.2442 mL | 5.6104 mL | |
| 15 mM | 0.1496 mL | 0.7481 mL | 1.4961 mL | 3.7403 mL | |
| 20 mM | 0.1122 mL | 0.5610 mL | 1.1221 mL | 2.8052 mL | |
| 25 mM | 0.0898 mL | 0.4488 mL | 0.8977 mL | 2.2442 mL | |
| 30 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8701 mL | |
| 40 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4026 mL | |
| 50 mM | 0.0449 mL | 0.2244 mL | 0.4488 mL | 1.1221 mL | |
| 60 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL | |
| 80 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.7013 mL | |
| 100 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5610 mL |
Metopimazine 関連分類
HY-116578 関連分類
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