Nav1.8-IN-7
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2761181-58-0
- 分子式: C22H18ClF4N3O5
- 分子量:515.84
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Nav1.8-IN-9 (Example 116; 1 μM) shows inhibitions of 1.2％, 3.7％, <1％, <1％, 2.6％, <1％ for Nav1.1, Nav1.3, Nav1.4, Nav1.5, Nav1.6, and Nav1.7, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
| PO (100 mg/kg) | |
| Cmax (ng/mL) | 2566 |
| AUC0-24 (ng/mL∗h) | 42454 |
| t1/2 (h) | 8.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2761181-58-0
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分子量 515.84
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分子式 C22H18ClF4N3O5
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SMILES
OC[C@@H](O)COC1=CC(NC(C(C=C(C(C(F)(F)F)=C2)Cl)=C2OC3=C(C=C(C=C3)F)C)=O)=CN=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
体内:
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nav1.8-IN-7 関連分類
HY-160588 関連分類
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