NHNB
NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 106359-61-9
- 分子式: C17H13NO2
- 分子量:263.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hHDAC8 66 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | IC50 |
0.18 μM
Compound: 16
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In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
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[PMID: 2308149] |
| RBL-1 | IC50 |
0.18 μM
Compound: 49
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In vitro inhibitory activity against RBL-1 5-LO
In vitro inhibitory activity against RBL-1 5-LO
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[PMID: 3820229] |
NHNB (Compound 4) inhibits recombinant human HDAC8 with an IC50 of 66.0 μM[1].
NHNB (0-5000 μM; 5 min) acts as a competitive inhibitor of purified B. cereus BC1974 peptidoglycan deacetylase with an IC50 of 43.3 μM and a Ki of 8.7 μM[2].
NHNB (0-5000 μM; 10 min) acts as a competitive inhibitor of purified B. cereus BC1960 peptidoglycan deacetylase with an IC50 of 132 μM and a Ki of 66.0 μM[2].
NHNB (4 μg/mL; 16 h) induces onger chains of daughter cell production in B. cereus and B. anthracis[2].
NHNB shows MICs of 5.26-7.89 μg/mL and MBcs of 8.23 μg/mL for B. cereus ATCC
14,579 and B. anthracis 7702[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 106359-61-9
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分子量 263.29
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分子式 C17H13NO2
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SMILES
O=C(C1=CC=C(C2=CC=CC3=C2C=CC=C3)C=C1)NO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007;17(10):2874-2878. [Content Brief]
[2]. Balomenou S, et al. Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus. Bioorg Med Chem. 2018;26(13):3845-3851. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NHNB 関連分類
HY-115442 関連分類
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