CDC7
null CDC7 is the catalytic subunit of Dbf4-dependent kinase (DDK), an S-phase-activating serine/threonine kinase named for its yeast cell-division-cycle mutant. Together with the regulatory subunits DBF4 (ASK) or DRF1, CDC7 phosphorylates the MCM2-7 helicase complex and other replication factors to trigger the G1/S transition and initiation of DNA replication. CDC7 expression is cell-cycle regulated and elevated in many tumors, while normal tissues appear relatively tolerant of its inhibition, which has made CDC7/DBF4 a prominent anticancer target pursued with small-molecule inhibitors. Recombinant CDC7, with or without DBF4, supports studies of replication initiation, checkpoint signaling and DDK inhibitor screening.
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CDC7 組換えタンパク質 (1)
- 生物種:
- 由来:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
