Sudemycin D6
Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and SRRM1 pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1510837-67-8
- 分子式: C27H42N2O5
- 分子量:474.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
50 nM
Compound: 3, sudemycin D6
|
Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| JeKo-1 | IC50 |
22 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| PC-3 | IC50 |
142 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| SK-MEL-2 | IC50 |
39 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
| SK-N-AS | IC50 |
81 nM
Compound: 3, sudemycin D6
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Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay
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[PMID: 24325474] |
化学情報
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CAS 番号 1510837-67-8
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分子量 474.63
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分子式 C27H42N2O5
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SMILES
CNC(O[C@@H](C)/C=C\C(N[C@@H](CC1)CC[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Shirai CL, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017 Jan 9;8:14060. [Content Brief]
[2]. Thurman M, et al. Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6. Biomark Insights. 2017 Sep 12;12:1177271917730557. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sudemycin D6 関連分類
HY-139499 関連分類
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