AChE/BuChE-IN-3
AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease.
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- CAS No.: 2742707-47-5
- 화학식: C30H30F3N3O6
- 분자량:585.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
AChE 0.65 μM (IC50) |
BChE 5.77 μM (IC50) |
In Vitro
AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:12.5 μM, 25 μM, 50 μM and 100 μM
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Incubation Time:48 hours
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Result:Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities.
Chemical Information
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CAS No. 2742707-47-5
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분자량 585.57
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화학식 C30H30F3N3O6
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SMILES
FC(C1=CC=C(CN2N=NC(COC3=CC(OC)=C4CCC(C5=CC(OC)=C(OC)C(OC)=C5)OC4=C3)=C2)C=C1)(F)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BuChE-IN-3 Related Classifications
HY-147939 Related Classifications
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