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Cat. No.: HY-112823S

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Almonertinib-d₆

Name: Almonertinib-d6
Brand: MedChemExpress
SKU: HY-112823S
Price: 1000.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: HS-10296-d₆)

Almonertinib-d₆ (HS-10296-d₆) is the deuterium labeled Almonertinib (HY-112823). Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₀H₂₉D₆N₇O₂
분자량:531.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Almonertinib-d₆ Chemical Structure

사이즈

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Biological Activity
- 제품 설명
- In Vitro
- 신청
Chemical Information
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Calculators
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Classifications
Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 1899921-05-1
분자량 531.68
화학식 C₃₀H₂₉D₆N₇O₂
SMILES

COC1=C(NC2=NC(C3=CN(C4=C3C=CC=C4)C5CC5)=CC=N2)C=C(NC(C=C)=O)C(N(CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C)=C1
Synonyms

HS-10296-d₆
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.