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Cat. No.: HY-117435

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CIDD 0067106

CIDD-0067106 is a selective mTORC1 pathway inhibitor targeting androgen receptor-positive (AR+) triple-negative breast cancer (TNBC). CIDD-0067106 demonstrates potent inhibition of AR+ TNBC cell lines with an GI₅₀ value of 0.8 μM. CIDD-0067106 is promising for research of AR+ TNBC.

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CAS No.: 2151865-39-1
화학식: C₂₆H₂₉N₃O₄
분자량:447.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CIDD 0067106 Chemical Structure

CAS No.: 2151865-39-1

사이즈

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재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

mTORC1

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A10	GI₅₀	35 μM Compound: 30	Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
BT-549	GI₅₀	40 μM Compound: 30	Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1806	GI₅₀	30 μM Compound: 30	Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1937	GI₅₀	35 μM Compound: 30	Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-231	GI₅₀	50 μM Compound: 30	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-453	GI₅₀	0.8 μM Compound: 30	Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
SUM185PE	GI₅₀	1.6 μM Compound: 30	Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]

Chemical Information

CAS No. 2151865-39-1
분자량 447.54
화학식 C₂₆H₂₉N₃O₄
SMILES

C(C1=CC=C(C=2OC(=CN2)C3=CC=C(OCC=C(C)C)C=C3)N=C1)N4[C@H](C(OC)=O)CCC4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Robles AJ, et al. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 Nov 22;60(22):9275-9289. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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CAS No.:
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CIDD 0067106

All mTOR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CIDD 0067106 Related Classifications

HY-117435 Related Classifications