FZ1 peptide
Based on 1 Customer Validation
FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist. FZ1 peptide activates the FAK/PI3K-AKT/ERK pathway and upregulates VEGFC to promote angiogenesis. FZ1 peptide exhibits antibacterial activity in extracts of HA-c-FZ1 hydrogel; it inhibits LPS-induced proinflammatory cytokine secretion in RAW264.7 macrophages; it reduces H2O2-induced ROS levels; it increases the healing rate of scratch wounds. FZ1 peptide can be used in studies related to diabetic skin wounds.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.92%
- 화학식: C29H49N9O12S2
- 분자량:779.88
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보관:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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αvβ3 |
ERK1 |
ERK2 |
IL-6 |
TNF-α |
FZ1 peptide (10 nM) shows the highest drug loading content (12.26%) and drug loading efficiency (83.12%) among all tested formulations when incorporated into the 4% (w/v) HA-c-FZ1 hydrogel[1].
FZ1 peptide (2-4% (w/v)) is released from HA-c-FZ1 hydrogel in a pH-dependent manner, with an accelerated release rate under acidic conditions matching the early inflammatory phase of diabetic wounds, which supports pathologically coupled peptide delivery[1].
FZ1 peptide (2-4% (w/v); 24 h) shows no cytotoxicity to HaCaT keratinocytes, HSFs, RAW264.7 macrophages and HUVECs in HA-c-FZ1 hydrogel extracts, and the 4% formulation significantly promotes cell proliferation[1].
FZ1 peptide (4% (w/v)) activates the pro-angiogenic signaling pathways of ERK, AKT, and FAK in HUVECs within HA-c-FZ1 hydrogel extracts[1].
FZ1 peptide (2-4% (w/v)) exhibits antibacterial activity against S. aureus and E. coli in extracts of HA-c-FZ1 hydrogels; it inhibits LPS-induced secretion of proinflammatory cytokines (IL-6, TNF-α) in RAW264.7 macrophages in a concentration-dependent manner; it reduces intracellular ROS levels in H2O2-treated HUVECs in a concentration-dependent manner; and it promotes migration of HaCaT keratinocytes and increases the healing rate of scratch wounds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 779.88
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화학식 C29H49N9O12S2
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Color White to off-white
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Sequence
Cys-Lys-Leu-Ser-Asn-Asp-Cys (Disulfide bridge: Cys1-Cys7)
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Sequence Shortening
CKLSNDC (Disulfide bridge: Cys1-Cys7)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
H2O : ≥ 100 mg/mL (128.22 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2822 mL | 6.4112 mL | 12.8225 mL | 32.0562 mL |
| 5 mM | 0.2564 mL | 1.2822 mL | 2.5645 mL | 6.4112 mL | |
| 10 mM | 0.1282 mL | 0.6411 mL | 1.2822 mL | 3.2056 mL | |
| 15 mM | 0.0855 mL | 0.4274 mL | 0.8548 mL | 2.1371 mL | |
| 20 mM | 0.0641 mL | 0.3206 mL | 0.6411 mL | 1.6028 mL | |
| 25 mM | 0.0513 mL | 0.2564 mL | 0.5129 mL | 1.2822 mL | |
| 30 mM | 0.0427 mL | 0.2137 mL | 0.4274 mL | 1.0685 mL | |
| 40 mM | 0.0321 mL | 0.1603 mL | 0.3206 mL | 0.8014 mL | |
| 50 mM | 0.0256 mL | 0.1282 mL | 0.2564 mL | 0.6411 mL | |
| 60 mM | 0.0214 mL | 0.1069 mL | 0.2137 mL | 0.5343 mL | |
| 80 mM | 0.0160 mL | 0.0801 mL | 0.1603 mL | 0.4007 mL | |
| 100 mM | 0.0128 mL | 0.0641 mL | 0.1282 mL | 0.3206 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
FZ1 peptide Related Classifications
HY-P11474 Related Classifications
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