Il6st - interleukin 6 signal transducer Gene

Also Known as CD130; gp130; D13Ertd699e; 5133400A03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16195

Summary

Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach Cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st Products (1)

mRNA	Protein	Name
NM_010560.3	NP_034690.3	interleukin-6 receptor subunit beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to interleukin-11 binding	IDA IDA: Inferred from direct assay	7957045	MGI
contributes to interleukin-11 receptor activity	IDA IDA: Inferred from direct assay	7957045	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16452727	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	7957045	MGI
acts upstream of or within glycogen metabolic process	IMP IMP: Inferred from mutant phenotype	10205167	MGI
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	25731159	MGI
involved in intestinal epithelial cell development	IDA IDA: Inferred from direct assay	25731159	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25731159	MGI
acts upstream of or within positive regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10486560	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15051883	MGI
acts upstream of or within regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	12629177	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12147685	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	10989258	MGI
located in dendrite	IDA IDA: Inferred from direct assay	10989258	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11275690	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	10989258	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-6 receptor subunit beta	IL-6 receptor subunit beta IL-6R subunit beta IL-6R-beta IL-6RB membrane glycoprotein 130 oncostatin-M receptor subunit alpha

Recombinant Il6st Proteins

Cat. No.	상품명	Accession	Purity
HY-P76370	gp130/IL6ST Protein, Mouse (HEK293, Fc)	Q00560/NP_034690 (Q23-E617)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76371	gp130/IL6ST Protein, Mouse (HEK293, His)	Q00560/NP_034690 (Q23-E617)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS06778	IL6ST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17230	Il6st Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23683	Il6st Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il6st	NCBI	NCBI:3572