CPNE1 - copine 1 Gene

Also Known as CPN1; COPN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8904

About CPNE1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,626,044-35,664,900 (from NCBI)

This gene has 28 transcripts (splice variants), 177 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 33.6), placenta (RPKM 33.3) and 25 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an Integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

CPNE1 Products (6)

mRNA	Protein	Name
NM_001198863.2	NP_001185792.1	copine-1 isoform c
NM_003915.6	NP_003906.2	copine-1 isoform b
NM_152925.3	NP_690902.1	copine-1 isoform a
NM_152926.3	NP_690903.1	copine-1 isoform a
NM_152927.3	NP_690904.1	copine-1 isoform a
NM_152928.3	NP_690905.1	copine-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	18212740	GOA
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	25450385	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18212740	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18212740	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	9430674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12522145	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	14674885	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	18212740	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18212740	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18212740	GOA
involved in neuron projection extension	IDA IDA: Inferred from direct assay	23263657	GOA
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	25450385	GOA
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	23263657	GOA
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	25450385	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23263657	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	25450385	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	14674885	GOA
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	18212740	GOA
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	14674885	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21087455	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12949241	GOA
located in membrane	IDA IDA: Inferred from direct assay	25450385	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18212740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE1 Protein Structure

C2

Copine

0
100
200
300
400
500
537 a.a.

Protein Preferred Names	Protein Names
copine-1	chromobindin 17

CPNE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CPNE1	Q99829	LHX6	Homo sapiens	Q9UPM6	Y2H Prey Pooling	32296183
Intra	CPNE1	Q99829	LHX6	Homo sapiens	Q9UPM6	Validated Y2H	32296183
Intra	CPNE1	Q99829	LHX6	Homo sapiens	Q9UPM6	Y2H Array	32296183
Intra	CPNE1	Q99829	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CPNE1	Q99829	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CPNE1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P70097	Copine-1/CPNE1 Protein, Human (His)	Q99829 (M1-A537)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Schizophrenia 19	SCZD19 Schizophrenia 19 With Or Without An Affective Disorder Schizophrenia 19, Susceptibility To {Schizophrenia 19, Susceptibility To}

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03103	CPNE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19422	Cpne1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25913	Cpne1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CPNE1	VGNC	VGNC:99050
Mus musculus	CPNE1	MGD	MGI:2386621
Rattus norvegicus	CPNE1	RGD	RGD:1311148
Canis familiaris	CPNE1	VGNC	VGNC:39560
Bos taurus	CPNE1	VGNC	VGNC:27658
Others	CPNE1	NCBI