Lovastatin acid
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia.
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- CAS No.: 75225-51-3
- 화학식: C24H38O6
- 분자량:422.55
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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HY-100793
SR12813HMG-CoA Reductase Inhibitor/hPXR Agonist -
HY-17504B
Rosuvastatin SodiumHMGCR Inhibitor -
HY-104051
Monacolin JCholesterol Biosynthesis Inhibitor -
HY-19671
ApomineHMGR Inhibitor -
HY-114316
HMG499HMG-CoA Inhibitor -
HY-129458
CerivastatinHMG-CoA Reductase Inhibitor -
HY-100793R
SR12813 (Standard)HMG-CoA Reductase Inhibitor/hPXR Agonist -
HY-17504BR
Rosuvastatin Sodium (Standard)Reference Standard -
HY-17504C
(3R,5R)-RosuvastatinhERG Potassium Channel Blocker/HMG-CoA Reductase Inhibitor
Biological Activity
제품 설명
IC50 & Target
Ki: 0.6 nM (HMG-CoA reductase)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
4 μM
Compound: Lovastatin acid
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TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17beta-glucuronide:0.02uM) in OATP1B1-expressing HEK293 cells
TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17beta-glucuronide:0.02uM) in OATP1B1-expressing HEK293 cells
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[PMID: 15616150] |
In Vitro
Lovastatin acid (Compound sodium mevinolinate) potently inhibits partially purified activated HMG-CoA reductase with a competitive Ki of 0.64 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75225-51-3
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분자량 422.55
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화학식 C24H38O6
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SMILES
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O
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Synonyms
Mevinolinic acid; MSD803
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Structure Classification
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lovastatin acid Related Classifications
HY-122439 Related Classifications
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