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Cat. No.: HY-137500

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NT1-O14B

Name: NT1-O14B
Brand: MedChemExpress
SKU: HY-137500
Price: 50.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

NT1-O14B is a tryptamine-derived lipidoid. NT1-O14B incorporates NT-lipidoid into BBB-impermeable lipid nanoparticles (LNPs), enabling the LNPs to cross the BBB. NT1-O14B enhances brain delivery via intravenous injection. NT1-O14B can be used in ischemic stroke research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.43%
CAS No.: 2739805-64-0
화학식: C₄₀H₆₈N₂O₄S₄
분자량:769.24

보관:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

NT1-O14B Chemical Structure

CAS No.: 2739805-64-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
Protocol (1)
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NT1-014B 用于制备平均粒径在 140-170 nm 的 LNP3^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

LNP3 (containing NT1-014B; intranasally administered) has a weaker fluorescence signal in the brain of mice with photothrombosis (PT)-induced ischemic stroke and is less efficient in delivering circSCMH1 to the brain than LNP1 and LNP2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2739805-64-0
Appearance Viscous Liquid
분자량 769.24
화학식 C₄₀H₆₈N₂O₄S₄
Color Colorless to light yellow
SMILES

O=C(CCN(CCC(OCCSSCCCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)OCCSSCCCCCCCCCC
선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Acta Biomater

Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery. [Abstract]

2025 Oct 11:S1742-7061(25)00762-7. PMID: 41083040
Mol Pharm

Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina. [Abstract]

2026 May 4;23(5):2944-2954. PMID: 41931102

용액&용해도

In Vitro:

DMSO : 150 mg/mL (195.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (130.00 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3000 mL

6.4999 mL

12.9998 mL

5 mM

0.2600 mL

1.3000 mL

2.6000 mL

10 mM

0.1300 mL

0.6500 mL

1.3000 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Protocol

All Animals and Diseases

How to Select the Route of Administration for Mammals
Route-of-administration selection in mammals is a pharmacokinetic, pharmacodynamic, formulation, animal-welfare, and translational decision, not a default technical choice. The selected route should match the study goal: intravenous dosing is most useful when complete systemic exposure and rapid onset are required, oral dosing is most translational for orally intended medicines but is affected by absorption and first-pass metabolism, subcutaneous or intramuscular dosing can provide slower systemic exposure, and intraperitoneal dosing can be useful in rodent proof-of-concept studies but may have limited clinical translation. Published route-comparison studies show that the same compound can produce different exposure, onset, bioavailability, tissue distribution, and tolerability depending on route; therefore, route choice should be supported by pilot pharmacokinetic or pharmacodynamic evidence when the literature is insufficient. Unresolved questions include how to standardize route sel

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020 Jul 24;6(30):eabb4429. [Content Brief]

[2]. Jia Y, et al. Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. Adv Mater. 2025 Mar 27:e2500598. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	1.3000 mL	6.4999 mL	12.9998 mL	32.4996 mL
	5 mM	0.2600 mL	1.3000 mL	2.6000 mL	6.4999 mL
	10 mM	0.1300 mL	0.6500 mL	1.3000 mL	3.2500 mL
	15 mM	0.0867 mL	0.4333 mL	0.8667 mL	2.1666 mL
	20 mM	0.0650 mL	0.3250 mL	0.6500 mL	1.6250 mL
	25 mM	0.0520 mL	0.2600 mL	0.5200 mL	1.3000 mL
	30 mM	0.0433 mL	0.2167 mL	0.4333 mL	1.0833 mL
	40 mM	0.0325 mL	0.1625 mL	0.3250 mL	0.8125 mL
	50 mM	0.0260 mL	0.1300 mL	0.2600 mL	0.6500 mL
	60 mM	0.0217 mL	0.1083 mL	0.2167 mL	0.5417 mL
	80 mM	0.0162 mL	0.0812 mL	0.1625 mL	0.4062 mL
	100 mM	0.0130 mL	0.0650 mL	0.1300 mL	0.3250 mL

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
Protocol
순도&문서
References

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NT1-O14B

Publications Citing Use of MedChemExpress (MCE) NT1-O14B