Oleandrigenin
Based on 1 Customer Validation
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.42%
- CAS No.: 465-15-6
- 화학식: C25H36O6
- 분자량:432.55
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 12
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Viability of human A549 cells by MTT assay after 24 hrs
Viability of human A549 cells by MTT assay after 24 hrs
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[PMID: 17595134] |
| A549 | IC50 |
0.36 μM
Compound: 12
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Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr
Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr
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[PMID: 17595134] |
| A549 | IC50 |
0.52 μM
Compound: 12
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Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr
Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr
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[PMID: 17595134] |
| BJ | IC50 |
0.1 μM
Compound: 2
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Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| BJ | IC50 |
0.1 μM
Compound: 2
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Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| CCRF-CEM | IC50 |
0.2 μM
Compound: 2
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Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| CCRF-CEM | IC50 |
0.2 μM
Compound: 2
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Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| HeLa | IC50 |
0.2 μM
Compound: 2
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| HeLa | IC50 |
0.2 μM
Compound: 2
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| HepG2 | IC50 |
0.2 mM
Compound: 12
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Growth inhibition of human HepG2 cells
Growth inhibition of human HepG2 cells
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[PMID: 17595134] |
| MCF7 | IC50 |
0.8 μM
Compound: 2
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| MCF7 | IC50 |
0.8 μM
Compound: 2
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| WI-38 | IC50 |
1.7 mM
Compound: 12
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Growth inhibition of human WI38 cells
Growth inhibition of human WI38 cells
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[PMID: 17595134] |
| WI-38 VA13 | IC50 |
0.16 mM
Compound: 12
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Growth inhibition of human VA13 cells
Growth inhibition of human VA13 cells
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[PMID: 17595134] |
Chemical Information
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CAS No. 465-15-6
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Appearance Solid
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분자량 432.55
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화학식 C25H36O6
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Color White to off-white
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SMILES
O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86(15):10249-10262. [Content Brief]
[2]. Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oleandrigenin Related Classifications
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