PIKK
PI3K-related kinases (PIKKs) are six giant Ser/Thr kinases whose catalytic cores resemble PI3K lipid kinases rather than classical protein kinases: ATM, ATR, DNA-PKcs, mTOR, SMG1, and the pseudokinase TRRAP. ATM, ATR, and DNA-PKcs lead the DNA damage response, phosphorylating H2AX, p53, CHK1/CHK2, and hundreds of other substrates after double-strand breaks or replication stress. mTOR nucleates the nutrient-sensing complexes mTORC1 and mTORC2 that control growth, metabolism, and autophagy. SMG1 guards mRNA quality through nonsense-mediated decay, and TRRAP scaffolds histone acetyltransferase complexes without catalytic activity. PIKKs are central to genome-stability, aging, and cancer research, anchor approved and investigational drugs such as mTOR and ATR inhibitors, and recombinant PIKKs serve kinase and inhibitor screening.
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PIKK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
