STING Degrader-3

STING Degrader-3 (Compound P8) (0.076-20 μM; 3-36 h) potently degrades STING protein in THP-1 cells, with a DC₅₀ of 2.58 μM at 24 h, and exhibits time- and dose-dependent activity^[1].
STING Degrader-3 (2.5-40 μM; 24 h) selectively degrades STING protein in THP-1 cells without affecting inflammation-related proteins STAT3 or AKT^[1].
STING Degrader-3 (3-10 μM; 12-48 h) degrades STING protein in THP-1 cells via the lysosomal pathway (rather than the proteasomal pathway), without affecting STING mRNA levels, and STING protein expression recovers within 24 h after removal of the compound^[1].
STING Degrader-3 (0.3-20 μM, 0-48 h) inhibits the activation of cGAMP (HY-12512)-induced STING downstream signaling pathway in THP-1 cells, reduces the phosphorylation levels of TBK1 and IRF3, and downregulates the mRNA levels of pro-inflammatory cytokines and interferon-stimulated genes^[1].
STING Degrader-3 (0.3-30 μM; 24 h, 1 h pretreatment + 24 h stimulation) acts as a STING pathway inhibitor (rather than a degrader) in RAW264.7 cells. It reduces DMXAA (HY-10964)-induced downstream signal transduction and mRNA levels of proinflammatory mediators without altering STING protein levels^[1].
STING Degrader-3 (0.33-90 μM; 48 h) exhibits low cytotoxicity in normal human HEK293T and HUVEC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.