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Cat. No.: HY-P10698

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VH-N412

VH-N412 is a vectorized neuropeptide (NT) with good blood-brain barrier permeability. VH-N412 binds to the low-density lipoprotein receptor (LDLR) and neuropeptide receptor 1 (NTSR-1), and acts as a pharmacological-induced hypothermia (PIH) inducer. VH-N412 exhibits anticonvulsant and neuroprotective effects, and can be used in the study of neurological diseases such as epilepsy.

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CAS No.: 1801681-81-1
화학식: C₉₄H₁₆₃N₂₇O₂₄S₃
분자량:2151.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VH-N412 Chemical Structure

CAS No.: 1801681-81-1

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Chemical Information

CAS No. 1801681-81-1
분자량 2151.66
화학식 C₉₄H₁₆₃N₂₇O₂₄S₃
Sequence

Pr-{d-Cys}-Met-{Pip}-Arg-Leu-Arg-{Sar}-Cys-{PEG6}-Arg-Arg-Pro-Tyr-Ile-Leu-OH (Disulfide bridge: Cys1-Cys8)
Sequence Shortening

Pr-{d-Cys}-M-{Pip}-RLR-{Sar}-C-{PEG6}-RRPYIL-OH (Disulfide bridge: Cys1-Cys8)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ferhat L, et al. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice[J]. bioRxiv, 2024: 2024.07. 15.603208.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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