Lancifodilactone N
Lancifodilactone N is a nortriterpenoid found in the leaves and stems of Schisandra lancifolia. Lancifodilactone N shows anti-HIV-1 activity and can be used for the research of HIV-1 infection.
For research use only. We do not sell to patients.
- CAS No.: 883153-36-4
- Formula: C29H34O10
- Molecular Weight:542.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
186.3 μg/mL
Compound: 6
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Cytotoxicity against human C8166 cells by MTT method
Cytotoxicity against human C8166 cells by MTT method
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[PMID: 16643044] |
In Vitro
Lancifodilactone N (Compound 6) inhibits HIV-1-induced cytopathic effects in C8166 cells with an EC50 of 77.6 μg/mL, shows cytotoxicity against C8166 cells with a CC50 of 186.3 μg/mL, and has a selectivity index of 2.4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 883153-36-4
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Molecular Weight 542.57
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Formula C29H34O10
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SMILES
O=C1[C@@]23[C@@]4([H])[C@@]([C@@H](C([C@]4(CC[C@]5(C1=CC[C@]6([H])[C@@]7([C@](CC(O7)=O)([H])OC6(C)C)C5)O3)C)=O)C)([H])[C@]8([H])[C@]([C@@](O)(C(O8)=O)C)([H])O2
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lancifodilactone N Related Classifications
HY-N19826 Related Classifications
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