2. PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. GSK-3 Apoptosis
  4. Lithium chloride hydrate

Lithium chloride hydrate  (Synonyms: hydrate/monohydrateortrihydrate)

Cat. No.: HY-W094474 Assay: 98.65%
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COA
Handling Instructions Technical Support

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease.

For research use only. We do not sell to patients.

Lithium chloride hydrate Chemical Structure

Lithium chloride hydrate Chemical Structure

CAS No. : 85144-11-2

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Based on 2 publication(s) in Google Scholar

Lithium chloride hydrate Related Antibodies

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Description

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3].

IC50 & Target[3]

GSK-3β

 

In Vitro

Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits cytopathy and IBV replication in IBV Beaudette-infected BHK cells[1].
Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits IBV-induced BHK cell apoptosis and inflammation[1].
Lithium chloride hydrate (1 mg/mL) improves the efficiency of induced pluripotent stem cell-derived neurospheres[4].
Lithium chloride hydrate (1.2 mM, 72 h) protects PC12 cells from Morphine (HY-P1701)-induced apoptosis[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lithium chloride hydrate Related Antibodies

RT-PCR[1]

Cell Line: BHK cells
Concentration: 5 and 20 mM
Incubation Time: 36 h
Result: Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β.
Blocked levels of Caspase-3, Bax and increased Bcl-2 level.
In Vivo

Lithium chloride hydrate (60 mg/kg, i.p., twice a day) improves Sevoflurane (SEV)-induced memory impairment in rats[2].
Lithium chloride hydrate (150 mg/kg, p.o., every other day) stimulates bone formation in extraction socket repair in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[5]
Dosage: 150 mg/kg
Administration: Oral administration (p.o.), every other day
Result: Produced greater proportion of newly formed bone (NB).
Lowered the rate of TRAP-stained cells.
Animal Model: Sevoflurane-induced memory impairment rats[2]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.), twice a day.
Result: Reduced escape latency, increased time in the objective quadrant and raised platform crossings.
Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus.
Molecular Weight

42.39 (anhydrous basis)

Formula

LiCl · xH2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Li]Cl.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL

DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.65%

SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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Lithium chloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithium chloride85144-11-2hydrate/monohydrateortrihydrateGSK-3ApoptosisGlycogen synthase kinase-3Glycogen synthase kinase 3Mood stabilizerviruscognition dysfunctiondepressionAlzheimer's diseaselearningmemoryInhibitorinhibitorinhibit

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