2. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Apoptosis
  3. GSK-3
    Apoptosis
  4. Lithium chloride hydrate

Lithium chloride hydrate  (Synonyms: hydrate/monohydrateortrihydrate)

Cat. No.: HY-W094474
COA Handling Instructions

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease.

For research use only. We do not sell to patients.

Lithium chloride hydrate Chemical Structure

Lithium chloride hydrate Chemical Structure

CAS No. : 85144-11-2

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Description

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3].

IC50 & Target[3]

GSK-3β

 

In Vitro

Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits cytopathy and IBV replication in IBV Beaudette-infected BHK cells[1].
Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits IBV-induced BHK cell apoptosis and inflammation[1].
Lithium chloride hydrate (1 mg/mL) improves the efficiency of induced pluripotent stem cell-derived neurospheres[4].
Lithium chloride hydrate (1.2 mM, 72 h) protects PC12 cells from Morphine (HY-P1701)-induced apoptosis[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: BHK cells
Concentration: 5 and 20 mM
Incubation Time: 36 h
Result: Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β.
Blocked levels of Caspase-3, Bax and increased Bcl-2 level.
In Vivo

Lithium chloride hydrate (60 mg/kg, i.p., twice a day) improves Sevoflurane (SEV)-induced memory impairment in rats[2].
Lithium chloride hydrate (150 mg/kg, p.o., every other day) stimulates bone formation in extraction socket repair in rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[5]
Dosage: 150 mg/kg
Administration: Oral administration (p.o.), every other day
Result: Produced greater proportion of newly formed bone (NB).
Lowered the rate of TRAP-stained cells.
Animal Model: Sevoflurane-induced memory impairment rats[2]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.), twice a day.
Result: Reduced escape latency, increased time in the objective quadrant and raised platform crossings.
Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus.
Molecular Weight

42.39 (anhydrous basis)

Appearance

Solid

Formula

LiCl · xH2O
CAS No.
SMILES

[Li]Cl.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Lithium chloride85144-11-2hydrate/monohydrateortrihydrateGSK-3ApoptosisGlycogen synthase kinase-3Glycogen synthase kinase 3Mood stabilizerviruscognition dysfunctiondepressionAlzheimer's diseaselearningmemoryInhibitorinhibitorinhibit

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