Lithium chloride hydrate
Based on 6 publication(s) in Google Scholar
Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 85144-11-2
- Formula: LiCl · xH2O
- Molecular Weight:42.39 (anhydrous basis)
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lithium chloride hydrate
More- Adv Sci (Weinh). 2025 Jul 23:e17248. [Abstract]
- Life Sci. 2026 Mar 1:388:124214. [Abstract]
- Drug Des Devel Ther. 2024 Aug 29:18:3903-3919. [Abstract]
- Eur J Pharmacol. 2025 Sep 15:1003:177900. [Abstract]
- Int Immunopharmacol. 2025 Sep 10:165:115526. [Abstract]
- Neurochem Int. 2024 Mar:174:105677. [Abstract]
Biological Activity
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GSK-3β |
Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits cytopathy and IBV replication in IBV Beaudette-infected BHK cells[1].
Lithium chloride hydrate (5 and 20 mM, 36 h) inhibits IBV-induced BHK cell apoptosis and inflammation[1].
Lithium chloride hydrate (1 mg/mL) improves the efficiency of induced pluripotent stem cell-derived neurospheres[4].
Lithium chloride hydrate (1.2 mM, 72 h) protects PC12 cells from Morphine (HY-P1701)-induced apoptosis[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BHK cells
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Concentration:5 and 20 mM
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Incubation Time:36 h
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Result:Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β.
Blocked levels of Caspase-3, Bax and increased Bcl-2 level.
Lithium chloride hydrate (150 mg/kg, p.o., every other day) stimulates bone formation in extraction socket repair in rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[5]
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Dosage:150 mg/kg
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Administration:Oral administration (p.o.), every other day
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Result:Produced greater proportion of newly formed bone (NB).
Lowered the rate of TRAP-stained cells.
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Animal Model:Sevoflurane-induced memory impairment rats[2]
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Dosage:60 mg/kg
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Administration:Intraperitoneal injection (i.p.), twice a day.
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Result:Reduced escape latency, increased time in the objective quadrant and raised platform crossings.
Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus.
Chemical Information
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CAS No. 85144-11-2
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Appearance Solid
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Molecular Weight 42.39 (anhydrous basis)
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Formula LiCl · xH2O
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Color White to off-white
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SMILES
[Li]Cl.O
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Synonyms
hydrate/monohydrateortrihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Restoration of SIRT3 Expression in Aged Mice Alleviates UUO-Induced Renal Fibrosis by Reducing GSK-3β Hyperacetylation. [Abstract]2025 Jul 23:e17248. PMID: 40698425 -
Life Sci
Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis. [Abstract]2026 Mar 1:388:124214. PMID: 41548594 -
Drug Des Devel Ther
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1. [Abstract]2024 Aug 29:18:3903-3919. PMID: 39224902 -
Eur J Pharmacol
Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis. [Abstract]2025 Sep 15:1003:177900. PMID: 40617384 -
Int Immunopharmacol
Aβ impairs bone vascular homeostasis in APP/PS1 mice via disrupting the mitochondrial fission-efferocytosis axis in macrophages. [Abstract]2025 Sep 10:165:115526. PMID: 40934542 -
Neurochem Int
H2S inhibits LiCl/pilocarpine-induced seizures and promotes neuroprotection by regulating TRPV2 expression via the AC3/cAMP/PKA pathway. [Abstract]2024 Mar:174:105677. PMID: 38290616
Solvent & Solubility
H2O : ≥ 50 mg/mL
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [Content Brief]
[2]. Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [Content Brief]
[3]. Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45(5):605-613. [Content Brief]
[4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [Content Brief]
[5]. Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lithium chloride hydrate Related Classifications
HY-W094474 Related Classifications
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