LMed 93
LMed 93 is an antiviral agent. LMed 93 inhibits the activity of influenza A virus RNA polymerase. LMed 93 suppresses viral RNA synthesis. LMed 93 inhibits the replication of influenza A viruses H5N1 and H1N1. LMed 93 can be used for the research of influenza A virus infections (H1N1, H5N1).
For research use only. We do not sell to patients.
- Formula: C19H13ClO5
- Molecular Weight:356.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK-II | EC50 |
5.66 μM
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Inhibition of Influenza A virus H1N1 (A/WSN/1933) replication in MDCK II cells assessed via Focus Forming Assay after 24 h incubation with simultaneous virus inoculation and reagent treatment.
Inhibition of Influenza A virus H1N1 (A/WSN/1933) replication in MDCK II cells assessed via Focus Forming Assay after 24 h incubation with simultaneous virus inoculation and reagent treatment.
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42485991 |
| MDCK-II | EC50 |
9.13 μM
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Inhibition of Influenza A virus H5N1 (A/Thailand/KAN-1/2004) replication in MDCK II cells assessed via Focus Forming Assay after 24 h incubation with simultaneous virus inoculation and reagent treatment.
Inhibition of Influenza A virus H5N1 (A/Thailand/KAN-1/2004) replication in MDCK II cells assessed via Focus Forming Assay after 24 h incubation with simultaneous virus inoculation and reagent treatment.
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42485991 |
LMed 93 (0.4-350 μM; 24 h) potently inhibits Influenza A virus H1N1 replication in MDCK II cells with an EC50 of 5.66 μM and a high selectivity index of >49.52[1].
LMed 93 (4.375-70 μM) inhibits Influenza A virus H5N1 replication in MDCK II cells with an EC50 of 9.13 μM and a high selectivity index of >30.71[1].
LMed 93 (70 μM) potently inhibits Influenza A virus H1N1 replication in MDCK II cells during early and intermediate infection stages (1 hpi and 3 hpi) but has reduced efficacy at late stages (6 hpi)[1].
LMed 93 (70 μM) significantly reduces viral genomic RNA (vRNA) levels in H1N1-infected MDCK II cells at all post-infection time points tested, without altering viral mRNA levels[1].
LMed 93 (35-70 μM; 20 h) modestly inhibits Influenza A virus RNA polymerase activity in MDCK II cells, reducing reporter activity by 38.7% at 35 μM and 53.7% at 70 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDCK II cells
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Concentration:70 μM
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Incubation Time:8 h (1 hpi to 9 hpi); 6 h (3 hpi to 9 hpi); 3 h (6 hpi to 9 hpi)
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Result:Reduced M1 vRNA levels by 82% (n-fold = 0.18) at 1 hpi.
Reduced M1 vRNA levels by 78% (n-fold = 0.22) at 3 hpi.
Reduced M1 vRNA levels by 60% (n-fold = 0.40) at 6 hpi.
Did not significantly reduce M1 or PB1 mRNA levels at any time point.
Chemical Information
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Molecular Weight 356.76
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Formula C19H13ClO5
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SMILES
ClC1=CC=C(OC(C(C(/C=C/C2=CC(OC)=C(O)C=C2)=O)=C3)=O)C3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LMed 93 Related Classifications
HY-187427 Related Classifications
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