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Manganese(salen) chloride (Synonyms: EUK-8)

Cat. No.: HY-W001583
Handling Instructions

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

For research use only. We do not sell to patients.

Manganese(salen) chloride Chemical Structure

Manganese(salen) chloride Chemical Structure

CAS No. : 53177-12-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

In Vitro

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3]
Dosage: 25 mg/kg/day
Administration: I.p. 3 times a week for 4 weeks
Result: Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress.
Prevented functional and geometrical deterioration in response to pressure overload.
Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
Molecular Weight

356.69

Formula

C₁₆H₁₄ClMnN₂O₂

CAS No.
SMILES

[Cl-][Mn+3]123[O-]C4=C(C=[N]1CC[N]2=CC5=C([O-]3)C=CC=C5)C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (23.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8036 mL 14.0178 mL 28.0355 mL
5 mM 0.5607 mL 2.8036 mL 5.6071 mL
10 mM 0.2804 mL 1.4018 mL 2.8036 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Manganese(salen)EUK-8EUK8EUK 8OtherssuperoxidedismutasecatalasemimeticantioxidantoxyradicalscavengingInhibitorinhibitorinhibit

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Manganese(salen) chloride
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