2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. MG624

MG624  (Synonyms: Stilonium iodide)

製品番号: HY-107672 純度: 97.30%
COA 取扱説明書 Technical Support

MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM.

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MG624

MG624 構造式

CAS 番号 : 77257-42-2

容量 価格（税別） 在庫状況 数量
5 mg $120 在庫あり
10 mg $198 在庫あり
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100 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

MG624 関連抗体

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製品説明

MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
4.7 μM
Compound: StN-2; MG624
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
[PMID: 30403486]
Astrocyte IC50
47 μM
Compound: StN-2; MG624
Cytotoxicity against mouse astrocytes assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against mouse astrocytes assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 30403486]
SH-SY5Y IC50
> 100 μM
Compound: StN-2; MG624
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTS assay
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTS assay
[PMID: 30403486]
U-87MG ATCC IC50
4.4 μM
Compound: StN-2; MG624
Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
[PMID: 30403486]
分子量

451.38

分子式

C22H30INO
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC[N+](CC)(CC)CCOC1=CC=C(/C=C/C2=CC=CC=C2)C=C1.[I-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (221.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2154 mL 11.0771 mL 22.1543 mL
5 mM 0.4431 mL 2.2154 mL 4.4309 mL
10 mM 0.2215 mL 1.1077 mL 2.2154 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 97.30%

COA (244 KB) HNMR (265 KB) LCMS (87 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2154 mL 11.0771 mL 22.1543 mL 55.3857 mL
5 mM 0.4431 mL 2.2154 mL 4.4309 mL 11.0771 mL
10 mM 0.2215 mL 1.1077 mL 2.2154 mL 5.5386 mL
15 mM 0.1477 mL 0.7385 mL 1.4770 mL 3.6924 mL
20 mM 0.1108 mL 0.5539 mL 1.1077 mL 2.7693 mL
25 mM 0.0886 mL 0.4431 mL 0.8862 mL 2.2154 mL
30 mM 0.0738 mL 0.3692 mL 0.7385 mL 1.8462 mL
40 mM 0.0554 mL 0.2769 mL 0.5539 mL 1.3846 mL
50 mM 0.0443 mL 0.2215 mL 0.4431 mL 1.1077 mL
60 mM 0.0369 mL 0.1846 mL 0.3692 mL 0.9231 mL
80 mM 0.0277 mL 0.1385 mL 0.2769 mL 0.6923 mL
100 mM 0.0222 mL 0.1108 mL 0.2215 mL 0.5539 mL
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MG624 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG62477257-42-2StiloniumMG 624MG-624nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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製品名:
MG624
製品番号:
HY-107672
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