2. Epigenetics
  3. Epigenetic Reader Domain
  4. MI-1481

MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression.

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MI-1481

MI-1481 Chemische Struktur

CAS. Nr. : 1887178-64-4

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Beschreibung

MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression[1].

Cellular Effect
Cell Line Type Value Description References
Bone marrow cell GI50
> 6 μM
Compound: (S)-28; MI-1481
Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay
[PMID: 29738674]
K562 GI50
> 6 μM
Compound: (S)-28; MI-1481
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay
[PMID: 29738674]
MOLM-13 GI50
61 nM
Compound: (S)-28; MI-1481
Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
[PMID: 29738674]
MV4-11 GI50
36 nM
Compound: (S)-28; MI-1481
Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
[PMID: 29738674]
U-937 GI50
> 6 μM
Compound: (S)-28; MI-1481
Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay
[PMID: 29738674]
Molekulargewicht

597.65

Formel

C29H30F3N7O2S
CAS. Nr.
SMILES

N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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MI-1481 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-14811887178-64-4MI1481MI 1481Epigenetic Reader DomainMenin-MLL1murine bone marrow cellsleukemiaInhibitorinhibitorinhibit

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