1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. N-Bromoacetyl-β-alanine

N-Bromoacetyl-β-alanine 

Cat. No.: HY-141379
Handling Instructions

N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

N-Bromoacetyl-β-alanine Chemical Structure

N-Bromoacetyl-β-alanine Chemical Structure

CAS No. : 89520-11-6

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100 mg USD 300 Ask For Quote & Lead Time
250 mg USD 540 Ask For Quote & Lead Time

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Description

N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target

Alkyl-Chain

 

Cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.03

Formula

C₅H₈BrNO₃

CAS No.

89520-11-6

SMILES

O=C(O)CCNC(CBr)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (297.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7612 mL 23.8061 mL 47.6122 mL
5 mM 0.9522 mL 4.7612 mL 9.5224 mL
10 mM 0.4761 mL 2.3806 mL 4.7612 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

N-Bromoacetyl-β-alaninePROTAC LinkerADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
N-Bromoacetyl-β-alanine
Cat. No.:
HY-141379
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