NF023 hexasodium

Name: NF023 hexasodium
Brand: MedChemExpress
SKU: HY-108676
Rating: 4.5 (1 reviews)

Cat. No.: HY-108676 Pureza: 99.99%: Ficha de datos
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NF023 hexasodium is a selective and competitive P2X₁ receptor antagonist, with IC₅₀ values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X₁, P2X₃, P2X₂, and P2X₄-mediated responses respectively.

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NF023 hexasodium Estructura química

No. CAS : 104869-31-0

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of NF023 hexasodium:

NF023 Obtener un presupuesto

1 Publications Citing Use of MCE NF023 hexasodium

•J Virol. 2024 Oct 30:e0119324. [Abstract]

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas P2X Receptor:

Ver todas las isoformas

P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

p2x1 Receptor

In Vitro

NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC₅₀ value of approximately 300 nM)^[2].
NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (K_B=1.190.2 μM)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF023 (100 μmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

1162.88

Fòrmula

C₃₅H₂₀N₄Na₆O₂₁S₆

No. CAS

104869-31-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : ≥ 116.3 mg/mL (100.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8599 mL	4.2997 mL	8.5993 mL
5 mM	0.1720 mL	0.8599 mL	1.7199 mL
10 mM	0.0860 mL	0.4300 mL	0.8599 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.99%

Select Batch:

Ficha de datos (277 KB) SDS (394 KB)

COA (252 KB) HNMR (449 KB) RP-HPLC (206 KB) MS (73 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38(1):141-9. [Content Brief]

[2]. M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49(4):602-11. [Content Brief]

[3]. G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):340-50. [Content Brief]

[4]. M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372(1):63-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.8599 mL	4.2997 mL	8.5993 mL	21.4983 mL
	5 mM	0.1720 mL	0.8599 mL	1.7199 mL	4.2997 mL
	10 mM	0.0860 mL	0.4300 mL	0.8599 mL	2.1498 mL
	15 mM	0.0573 mL	0.2866 mL	0.5733 mL	1.4332 mL
	20 mM	0.0430 mL	0.2150 mL	0.4300 mL	1.0749 mL
	25 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8599 mL
	30 mM	0.0287 mL	0.1433 mL	0.2866 mL	0.7166 mL
	40 mM	0.0215 mL	0.1075 mL	0.2150 mL	0.5375 mL
	50 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.4300 mL
	60 mM	0.0143 mL	0.0717 mL	0.1433 mL	0.3583 mL
	80 mM	0.0107 mL	0.0537 mL	0.1075 mL	0.2687 mL
	100 mM	0.0086 mL	0.0430 mL	0.0860 mL	0.2150 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.