2. Membrane Transporter/Ion Channel
  3. CFTR
  4. NJH-2-057

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

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NJH-2-057

NJH-2-057 構造式

CAS 番号 : 2858812-70-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 464 在庫あり
Solution
10 mM * 1 mL in DMSO USD 464 在庫あり
Solid
5 mg $260 在庫あり
10 mg $380 在庫あり
25 mg $800 在庫あり
50 mg $1280 在庫あり
100 mg $2100 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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NJH-2-057 関連抗体

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  • 純度とドキュメンテーション

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製品説明

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

分子量

810.84

分子式

C43H44F2N6O8
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(N(CC1)C2=CC=C(CCC(NCCCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)O2)=O)C=C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (123.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2333 mL 6.1664 mL 12.3329 mL
5 mM 0.2467 mL 1.2333 mL 2.4666 mL
10 mM 0.1233 mL 0.6166 mL 1.2333 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2333 mL 6.1664 mL 12.3329 mL 30.8322 mL
5 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
10 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
15 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0555 mL
20 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
25 mM 0.0493 mL 0.2467 mL 0.4933 mL 1.2333 mL
30 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0277 mL
40 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
50 mM 0.0247 mL 0.1233 mL 0.2467 mL 0.6166 mL
60 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5139 mL
80 mM 0.0154 mL 0.0771 mL 0.1542 mL 0.3854 mL
100 mM 0.0123 mL 0.0617 mL 0.1233 mL 0.3083 mL
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NJH-2-057 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJH-2-0572858812-70-9CFTRCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-115878
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