1. GPCR/G Protein
  2. Vasopressin Receptor
  3. Pecavaptan

Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.

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Pecavaptan Chemical Structure

Pecavaptan Chemical Structure

CAS No. : 1914998-56-3

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Description

Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].

IC50 & Target[1]

human V1a Receptor

3.6 nM (IC50)

canine V1a Receptor

4.4 nM (IC50)

human V2 Receptor

1.7 nM (IC50)

canine V2 Receptor

1.3 nM (IC50)

In Vivo

Pecavaptan (0.01, 0.03, 0.1 and 0.3 mg/kg; IV; single dose) protects from arginine vasopressin (AVP)-mediated cardiac output (CO) in canine tachypacing-induced model of heart failure (HF)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

543.33

Formula

C22H19Cl2F3N6O3

CAS No.
SMILES

O[C@H](C(F)(F)F)CN1C(C2=CC=C(Cl)C=C2)=NN(CC3=NN(C4=CC(Cl)=CC=C4)C([C@@H](O)C)=N3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Pecavaptan Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pecavaptan
Cat. No.:
HY-109133
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