1. Anti-infection
    Apoptosis
    Autophagy
  2. Bacterial
    Apoptosis
    Autophagy
  3. Pinosylvin

Pinosylvin 

Cat. No.: HY-N2387
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Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus spp, has anti-bacterial activities. Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells.

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Pinosylvin Chemical Structure

Pinosylvin Chemical Structure

CAS No. : 22139-77-1

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Description

Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus spp, has anti-bacterial activities[1]. Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells[2].

In Vitro

Pinosylvin (0-100 μM; 24 hours) is cytotoxic to THP‐1 and U937 cells, exhibits an IC50 value of 20-30 μM in leukemia cells, the maximal cytotoxic effect occurred at 100 μM following incubation for 24 hr[3].
Pinosylvin (0-100 μM; 24 hours) enhances the number of annexin V+ and PI+ cells in the U937 population at 50 μM, increases annexin V+ and PI+ cells in the THP‐1 population at 100 μM[3].
Pinosylvin (0-100 μM; 24 hours) promotes autophagy in leukemia cells by enhancing the level of LC3‐II and p62/SQSTM1 degradation in leukemia cells[3].

Cell Viability Assay[3]

Cell Line: Leukemia cells
Concentration: 0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM
Incubation Time: 24 hours
Result: Was cytotoxic to leukemia cells at high concentrations.

Apoptosis Analysis[3]

Cell Line: U937 and THP‐1 cells
Concentration: 0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM
Incubation Time: 24 hours
Result: Induced apoptosis cell number in U937 and THP‐1 cells.

Western Blot Analysis[3]

Cell Line: U937 and THP‐1 cells
Concentration: 0 μM; 0.1 μM; 1 μM; 10 μM; 50 μM; 100 μM
Incubation Time: 24 hours
Result: Induced autophagy in leukemia cells. 
In Vivo

Pinosylvin (intravenous injection; 10 mg/kg) yields the plasma AUC, urine t , CL and Vd values of 5.23 ± 1.20 mgh mL-1, 13.13 ± 2.05 h, 1.84 ± 0.44 Lh-1kg-1 and 2.29 Lkg-1, respectively in male Sprague-Dawley rats, in a PK study[1].

Molecular Weight

212.24

Formula

C₁₄H₁₂O₂

CAS No.

22139-77-1

SMILES

OC1=CC(/C=C/C2=CC=CC=C2)=CC(O)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PinosylvinBacterialApoptosisAutophagyleukemiaanti-bacterialapoptosisautophapyanalogueInhibitorinhibitorinhibit

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