Poloxamer 403 (P123)
Based on 1 Customer Validation
Poloxamer 403 P123 is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 5750. Poloxamer has the ability to inhibit P-gp. Poloxamer 403 increases creatine kinase levels. Poloxamer 403 is myotoxic.
For research use only. We do not sell to patients.
- CAS No.: 9003-11-6
- Molecular Weight:5750 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Poloxamer 403 can be used as a cosmetic ingredient[1].
Poloxamer has the ability to inhibit P-gp[2].
Poloxamer has been proposed as an agent carrier to improve agent efficacy and reduce side effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9003-11-6
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Appearance <50°C Solid,>52°C Liquid
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Molecular Weight 5750 (Average)
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Color Colorless to off-white
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SMILES
[Poloxamer 403 (P123)]
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Synonyms
PEG-PPG-PEG, 5750 (Average)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Johnston TP, et al., Toxicological evaluation of poloxamer vehicles for intramuscular use. J Parenter Sci Technol. 1985 Mar-Apr;39(2):83-9. [Content Brief]
[2]. Mello JC, et al. Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacol Res. 2016 Sep;111:102-112. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poloxamer 403 (P123) Related Classifications
HY-D1005A25 Related Classifications
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