1. PROTAC MAPK/ERK Pathway
  2. PROTACs Raf
  3. PROTAC BRAF-V600E degrader-2

PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth.

For research use only. We do not sell to patients.

PROTAC BRAF-V600E degrader-2 Chemical Structure

PROTAC BRAF-V600E degrader-2 Chemical Structure

CAS No. : 2417296-82-1

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Description

PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].

IC50 & Target[1]

BRAF-V600E

9.5 nM (Kd)

Braf

14.4 nM (Kd)

Cereblon

 

Molecular Weight

839.86

Formula

C42H39F2N7O8S

CAS No.
SMILES

O=C(NCC1=CC=C(C2=CN=C(NC=C3C(C4=C(F)C=CC(NS(=O)(CCC)=O)=C4F)=O)C3=C2)C=C1)CCCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PROTAC BRAF-V600E degrader-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC BRAF-V600E degrader-2
Cat. No.:
HY-137488
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