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Cat. No.: HY-178459

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PROTAC HPK1 Degrader-6

PROTAC HPK1 Degrader-6 is a potent HPK1 PROTAC degrader. PROTAC HPK1 Degrader-6 promotes ubiquitination and degradation of HPK1. PROTAC HPK1 Degrader-6 can be used in cancer research.
(Pink: HPK1 ligand (HY-179196); Blue: Cereblon ligand (HY-179197); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3099168-12-1
Formula: C₄₁H₄₃N₉O₃
Molecular Weight:709.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PROTAC HPK1 Degrader-6 Chemical Structure

CAS No.: 3099168-12-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC HPK1 Degrader-6 is a potent HPK1 PROTAC degrader. PROTAC HPK1 Degrader-6 promotes ubiquitination and degradation of HPK1. PROTAC HPK1 Degrader-6 can be used in cancer research^[1]. (Pink: HPK1 ligand (HY-179196); Blue: Cereblon ligand (HY-179197); Black: linker).

IC₅₀ & Target

^[1]

HPK1

<50 nM (IC₅₀)

Cereblon

All PROTACs Isoforms :

All MAP4K Isoforms :

In Vitro

PROTAC HPK1 Degrader-6 (Compound 314) degrades HPK1 in Jurkat cells with an IC₅₀ <50 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3099168-12-1
Molecular Weight 709.84
Formula C₄₁H₄₃N₉O₃
SMILES

O=C(N1)N(C2=CC=C(C3CCN(C4CN(C5=CC=C(NC6=NC=C7C=CC(C8=CN=C9OCCNC9=C8C)=CC7=N6)C=C5)C4)CC3)C=C2C)CCC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Momar TOURE, et al. Preparation of quinazoline heterobifunctional compounds for the degradation of HPK1. WO2025163390. WIPO (PCT). 2025-01-29.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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