Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities

  • J Antibiot (Tokyo). 2000 Aug;53(8):788-92. doi: 10.7164/antibiotics.53.788.
Y Masuoka  1 ,  K Shin-Ya ,  Y B Kim ,  M Yoshida ,  K Nagai ,  K Suzuki ,  Y Hayakawa ,  H Seto
Affiliations
  • 1. Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
PMID: 11079800 DOI: 10.7164/antibiotics.53.788
Abstract

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-beta-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in Mv1Lu cells with an IC50 value of 20.3 microM and inhibited histone deacetylase.

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