Cytotoxic constituents of Polyalthia longifolia var. pendula

  • J Nat Prod. 2000 Nov;63(11):1475-8. doi: 10.1021/np000176e.
C Y Chen  1 ,  F R Chang ,  Y C Shih ,  T J Hsieh ,  Y C Chia ,  H Y Tseng ,  H C Chen ,  S J Chen ,  M C Hsu ,  Y C Wu
Affiliations
  • 1. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
PMID: 11087586 DOI: 10.1021/np000176e
Abstract

A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.