Cytotoxic germacranolides from Inula verbascifolia subsp. methanea

  • J Nat Prod. 2002 Jul;65(7):1045-8. doi: 10.1021/np010569t.
Evagelia Harvala  1 ,  Nektarios Aligiannis ,  Alexios-Leandros Skaltsounis ,  Haris Pratsinis ,  George Lambrinidis ,  Catherine Harvala ,  Ioanna Chinou
Affiliations
  • 1. Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-15771, Athens, Greece.
PMID: 12141872 DOI: 10.1021/np010569t
Abstract

The aerial parts of Inula verbascifolia subsp. methanea yielded three new epoxygermacranolides, compounds 1-3, in addition to the previously known 9beta-hydroxyparthenolide. The structures of 1-3 have been elucidated on the basis of their spectral data (MS, CD, 1D and 2D NMR) and by quantum mechanical calculations. The in vitro cytotoxic activity of compounds 1-3 was evaluated against six human solid tumor cell lines.