[Cycloartane triterpenes and glycosides from Cimicifuga acerina]

  • Yao Xue Xue Bao. 2001 Apr;36(4):287-91.
Q W Zhang  1 ,  W C Ye ,  C T Che ,  S X Zhao
Affiliations
  • 1. Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China.
PMID: 12580058
Abstract

Aim: To investigate the chemical constituents from the rhizomes of Cimicifuga acerina (Sieb. et Zucc.) Tanaka.

Methods: Column chromatgraphy (including silica gel and ODS) together with HPLC was used to separate the chemical constituents whose structures were determined by FAB-MS, NMR (1D and 2D) and hydrolysis methods.

Results: Five cycloartane triterpenoids were isolated and identified as: (22R)-22-hydroxycimigenol (I), (22R)-22-hydroxy-24-O-acetylhydroshengmanol 3-O-beta-D-xylopyranoside (II), dahurinol (III), 24-epi-24-O-acetyl-7,8-didehydroshengmanol 3-O-beta-D-xylopyranoside (IV), 25-O-acetyl-7,8-didehydrocimigenol 3-O-beta-D-xylopyranoside (V).

Conclusion: Compound I is a new natural product, compound II is a new compound and compounds IV and V were isolated from this plant for the first time.

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