Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis

  • Chem Pharm Bull (Tokyo). 2003 Jul;51(7):790-3. doi: 10.1248/cpb.51.790.
Quan-Bin Han  1 ,  Ma-Lin Li ,  Sheng-Hong Li ,  Yi-Kun Mou ,  Zhong-Wen Lin ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
PMID: 12843583 DOI: 10.1248/cpb.51.790
Abstract

Four new ent-kaurane Diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.

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