Littorachalcone, a new enhancer of NGF-mediated neurite outgrowth, from Verbena littoralis

  • Chem Pharm Bull (Tokyo). 2003 Jul;51(7):872-4. doi: 10.1248/cpb.51.872.
Yushan Li  1 ,  Masami Ishibashi ,  Xigui Chen ,  Yasushi Ohizumi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
PMID: 12843601 DOI: 10.1248/cpb.51.872
Abstract

A new dihydrochalcone dimer, 2',4',3",2"',4"'-pentahydroxy-4-O-4"-tetrahydrobichalcone, given the name littorachalcone, was isolated from the aerial parts of Verbena littoralis H. B. K. along with two known Flavonoids 4'-hydroxywogonin and 8,3'-dimethoxy-5,7,4'-trihydroxyflavone. Littorachalcone caused a significant enhancement of nerve growth factor-mediated neurite outgrowth from PC12D cells.

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