Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):4107-11. doi: 10.1016/j.bmcl.2004.04.087.
Ahmed Kamal  1 ,  O Srinivas ,  P Ramulu ,  G Ramesh ,  P Praveen Kumar
Affiliations
  • 1. Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. [email protected]
PMID: 15225736 DOI: 10.1016/j.bmcl.2004.04.087
Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro Anticancer activity.