Antibacterial properties of the bicyclic pyrazolidinones

  • J Antibiot (Tokyo). 1990 Jan;43(1):92-9. doi: 10.7164/antibiotics.43.92.
N E Allen  1 ,  J N Hobbs Jr ,  D A Preston ,  J R Turner ,  C Y Wu
Affiliations
  • 1. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
PMID: 1689710 DOI: 10.7164/antibiotics.43.92
Abstract

LY173013 and LY186826 are bicyclic pyrazolidinones containing a novel aza-gamma-lactam ring structure. The Antibacterial properties of these compounds appear to be related to those of Beta-lactam Antibiotics in that both classes of compounds share certain common binding molecules such as beta-lactamases and penicillin-binding proteins.

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