Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

  • Phytochemistry. 2006 Dec;67(24):2651-8. doi: 10.1016/j.phytochem.2006.10.005.
Huizhen Liu  1 ,  Kent Gunnertoft Jensen ,  Linh My Tran ,  Ming Chen ,  Lin Zhai ,  Carl Erik Olsen ,  Helmer Søhoel ,  Samuel R Denmeade ,  John T Isaacs ,  S Brøgger Christensen
Affiliations
  • 1. Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
PMID: 17098264 DOI: 10.1016/j.phytochem.2006.10.005
Abstract

Four Phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the Phenylpropanoids has been developed. The Phenylpropanoids were found to be potent cytotoxins.

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