Sultam thiourea inhibition of West Nile virus

  • Antimicrob Agents Chemother. 2007 Jul;51(7):2642-5. doi: 10.1128/AAC.00007-07.
Eric Barklis  1 ,  Amelia Still ,  Mohammad I Sabri ,  Alec J Hirsch ,  Janko Nikolich-Zugich ,  James Brien ,  Tenzin Choesang Dhenub ,  Isabel Scholz ,  Ayna Alfadhli
Affiliations
  • 1. Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. [email protected]
PMID: 17452483 DOI: 10.1128/AAC.00007-07
Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.