Pyrimidine-based inhibitors of CaMKIIdelta

  • Bioorg Med Chem Lett. 2008 Apr 1;18(7):2404-8. doi: 10.1016/j.bmcl.2008.02.056.
Babu Mavunkel  1 ,  Yong-Jin Xu ,  Bindu Goyal ,  Don Lim ,  Qing Lu ,  Zheng Chen ,  Dan-Xiong Wang ,  Jeffrey Higaki ,  Indrani Chakraborty ,  Albert Liclican ,  Steve Sideris ,  Maureen Laney ,  Ulrike Delling ,  Rosanne Catalano ,  Linda S Higgins ,  Hui Wang ,  Jing Wang ,  Ying Feng ,  Sundeep Dugar ,  Daniel E Levy
Affiliations
  • 1. Scios, Inc., 6500 Paseo Padre Parkway, Fremont, CA 94555, USA.
PMID: 18334293 DOI: 10.1016/j.bmcl.2008.02.056
Abstract

Non-ATP competitive pyrimidine-based inhibitors of CaMKIIdelta were identified. Computational studies were enlisted to predict the probable mode of binding. The results of the computational studies led to the design of ATP competitive inhibitors with optimized hinge interactions. Inhibitors of this class possessed improved enzyme and cellular activity compared to early leads.

Products