Isoflavones and rotenoids from the leaves of Millettia brandisiana

  • Chem Pharm Bull (Tokyo). 2008 Jun;56(6):835-8. doi: 10.1248/cpb.56.835.
Orasa Pancharoen  1 ,  Anan Athipornchai ,  Ampai Panthong ,  Walter Charles Taylor
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand. [email protected]
PMID: 18520090 DOI: 10.1248/cpb.56.835
Abstract

A new isoflavone, 4'-gamma,gamma-dimethylallyloxy-5,7,2',5'-tetramethoxyisoflavone, brandisianin A (1), was isolated from the leaves of Millettia brandisiana, along with one synthetically known isoflavone, 7,4'-di-O-prenylgenistein (2) and twelve known compounds. The structures were elucidated on the basis of extensive spectroscopic analysis. Two isolated compounds were tested for anti-inflammatory activity; 12a-hydroxy-alpha-toxicarol (11) showed significant anti-inflammatory activity.

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