4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

  • Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. doi: 10.1016/j.bmcl.2008.06.076.
Rikki Alexander  1 ,  Ahrani Balasundaram ,  Mark Batchelor ,  Daniel Brookings ,  Karen Crépy ,  Tom Crabbe ,  Marie-France Deltent ,  Frank Driessens ,  Andrew Gill ,  Sue Harris ,  Gillian Hutchinson ,  Claire Kulisa ,  Mark Merriman ,  Prakash Mistry ,  Ted Parton ,  James Turner ,  Ian Whitcombe ,  Sara Wright
Affiliations
  • 1. Department of Medicinal Chemistry, UCB, 208 Bath Road, Slough, Berkshire SL1 3WE, UK. [email protected]
PMID: 18625552 DOI: 10.1016/j.bmcl.2008.06.076
Abstract

4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.

Products