[Study on antidepressant components of sucrose ester from Polygala tenuifolia]

  • Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(11):1278-80.
Hai-Hua Tu  1 ,  Ping Liu ,  Liang Mu ,  Hong-Bo Liao ,  Ting-Ting Xie ,  Li-Hua Ma ,  Yao-Ming Liu
Affiliations
  • 1. Dept of Clinical Pharmacology, General Hospital of PIM, Beijing 100853, China.
PMID: 18831206
Abstract

Objective: To investigate the antidepressant components of Polygala tenuifolia.

Method: The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities.

Result: Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.

Conclusion: Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.

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