Design and synthesis of vidarabine prodrugs as antiviral agents

  • Bioorg Med Chem Lett. 2009 Feb 1;19(3):792-6. doi: 10.1016/j.bmcl.2008.12.031.
Wei Shen  1 ,  Jae-Seung Kim ,  Phillip E Kish ,  Jie Zhang ,  Stefanie Mitchell ,  Brian G Gentry ,  Julie M Breitenbach ,  John C Drach ,  John Hilfinger
Affiliations
PMID: 19097789 DOI: 10.1016/j.bmcl.2008.12.031
Abstract

5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.